연세대학교 신소재공학과
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14년 신소재공학과 M.T

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Reciprocal Self-Assembly of Peptide-DNA Conjugates into a Programmable Sub-10-nm Supramolecular Deoxyribonucleoprotein

Prof. Yong-beom Lim's group has developed a programmable sub-10-nm supramolecular deoxyribonucleoprotein in which two orthogonal self-assembly modes, that is, β-sheet formation and Watson–Crick base pairing, are covalently combined in one supramolecular system. Covalently conjugated peptide-DNA conjugate building blocks are shown to assemble into well-defined and controllable nanostructures, and the resulting nanostructures showed gene regulation activity with low cytotoxicity.

Angew. Chem. Int. Ed., 2016, 55(39), 12003-12007.