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  • Reciprocal Self-Assembly of Peptide-DNA Conjugates into a Programmable Sub-10-nm Supramolecular Deoxyribonucleoprotein
  • 조회 수: 1171, 2016-10-04 12:20:56(2016-10-04)


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    Prof. Yong-beom Lim's group has developed a programmable sub-10-nm supramolecular deoxyribonucleoprotein in which two orthogonal self-assembly modes, that is, β-sheet formation and Watson–Crick base pairing, are covalently combined in one supramolecular system. Covalently conjugated peptide-DNA conjugate building blocks are shown to assemble into well-defined and controllable nanostructures, and the resulting nanostructures showed gene regulation activity with low cytotoxicity.

    link : http://onlinelibrary.wiley.com/doi/10.1002/anie.201605696/abstract

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